Global supply chain has become the most significant feature of the current world economy. In view of the current outbreak of normalized under special economic environment, it is necessary to exchange perspectives and functional paradigm to redefine China’s global manufacturing supply chain reconstruction and the content of the digital transition boundary and the core category, clarify the basic characteristics of stage performance, clearly identify the evolution of the whole domain forms, deeply understand the evolution of the power source. The specific paths for the reconstruction and digital transformation of the global supply chain of China’s manufacturing industry are further sorted out: First, the basic points: actively promote the integrated development of digital economy and real economy, and form the backbone of the strategy of manufacturing power. Second, key points: We will make every effort to build new national competitive advantages and explore the power of scientific and technological innovation to benefit all. Third, focus: comprehensively improve the governance system and mechanisms of the industrial chain and supply chain, and undertake the mission of opening up and facilitating double circulation. Fourth, focus: accelerate the construction of a modern economic system, as the pioneer of digital emission reduction. And then put forward a comprehensive, independent, coordinated, peaceful and inclusive Chinese approach to control the global supply chain initiative and achieve sustainable and healthy development of China’s economy.