As the international and domestic development situation becomes more complex and uncertain, the major decision-making of science and technology development and promotion of science and technology development is also more complex and uncertain, which puts forward higher requirements for the organization and comprehensive integration of major consulting projects. The think tank has set up a major consulting project, which aims to integrate the wisdom of experts from multiple disciplines, fields and subjects, and put forward professional, constructive, forward-looking and practical opinions and suggestions. This paper sorts out the research progress of major consulting project organization and comprehensive integration methods. Based on the double helix method of think tanks, it focuses on its applicability, steps and standards in the organization and comprehensive integration of major scientific and technical consulting projects, so as to ensure the “compliance” of different types of major consulting projects. “Mission positioning” matches “organization model” and “integration method” to better serve scientific decision-making.