Human capital accumulation largely depends on spillover, which exists not only among workers in different industries, but also between generations of Migrants. The accumulation of human capital of parents affects the education of offspring, which is very obvious in migrant families. Based on this, this paper attempts to empirically analyze the endogenous relationship between migration, human capital and economic growth by using provincial (municipal) panel data from 1999 to 2018 with the help of the hypothesis of intergenerational spillover on human capital. The results show that: (1) If the variables(technology, population and cost )remain unchanged, the larger the human capital stock in the area of inflow, the larger the number of highly skilled immigrants; (2) Skill-biased technology shock significantly increased the proportion of highly skilled labors in the migrants and strengthened the intergenerational spillover of human capital. (3) When reaching the new steady state, the growth path of regional economy will change significantly due to the distribution of highly skilled population.