It is of great significance to clarify how local governments promote the integrated innovation of large enterprises and small and medium-sized enterprises (SMEs). Based on the case of the construction of the public technical service center of SMEs in Yichang, this paper reveals the empowering mechanism of local government to promote the integrated innovation of large enterprises and SMEs through three empowering means such as meaning communication, power delegation and resource supply from the perspective of empowerment. The findings are as follows: First, activating the willingness of leading firms to provide technical services through meaning communication, guaranteeing the autonomy of leading firms in the public technical service platform and optimizing the environment for cooperative innovation of industry-university-research by power delegation, and supporting leading firms to form technical service projects that meet the innovation needs of SMEs and promote industry development through supplying government resources. Second, to stimulate the innovation motivation of SMEs through meaning communication and power delegation, to support the actions of SMEs to enhance their innovation ability through supplying government resources, thus pulling leading firms to provide technical services for them. Third, the above process solves the cooperation barriers caused by the heterogeneity of large enterprises and SMEs, thus realizing the integration of innovation elements. This paper supplements the research on government-led public technical service platform, and it expands the connotation of government empowerment.