In post epidemic Era，with the rapid development of new generation of information technology and the acceleration of enterprises digital transformation of, discussion of technology replacement in labor market has been once again triggered. It is crucial to promote industrial high-quality development and maintain employment by analysis enterprises digital transformation on employment structure. This paper takes China’s A-share manufacturing listed companies from 2013 to 2020 as a research sample, uses text mining technology to construct an enterprise digital transformation index, and empirically tests the employment structure effect in the digital transformation of enterprises. The results of the study found that with the deepening of enterprises digital transformation , the demand for technical, service-oriented and high-skilled talents has increased significantly, while a significant substitution effect has been generated for production-oriented and low-skilled employees. Further heterogeneity test found that the employment structure effect brought by digital transformation is more significant in large enterprises, state-owned enterprises, and the eastern region. In order to continue play the role of enterprises digital transformation on employment structure and promote the positive interaction between industrial transformation and employment, it is recommended to establish a talent policy that adapts to digital transformation according to local conditions.