To achieve the grand goal of improving the overall efficiency of the national innovation system and entering the forefront of innovative countries requires improving the new national system, promoting the coordination and linkage of the national innovation system and regional innovation system, Integrating top-level design with regional exploration from the bottom up. Firstly, improving the high-level coordination mechanism of the Party’s “trinity” of education, technology and talent, constructing the “Overall Design Department” under the New National System, adhering to the “two wheel drive” of scientific and technological innovation and institutional innovation, realizing the coordinated development of “hard technology” and “soft science”, and solving the “near worry” and “far concern” of scientific and technological development; The second is to continuously improve the efficient, collaborative, and open national innovation system, optimize the allocation mechanism of national innovation resources under market economy conditions, and create a technology governance system with diverse and interconnected entities; The third is to promote the deep integration of talent chain, innovation chain, industry chain, and capital chain, construct a “small environment” and “micro ecology” for innovation and entrepreneurship in a virtuous cycle, and further strengthen legal protection; Fourthly, leveraging the “two initiatives” of the central and local governments, and promoting collaborative interaction between regional innovation systems and national innovation systems; Fifthly, supporting a overseas Chinese scientists to “return home”, establishing a group of high-level research universities in the Guangdong-Hong Kong-Macao Greater Bay Area, forming an internationally competitive talent system, and accelerating the transformation of the Guangdong-Hong Kong-Macao Greater Bay Area into an international center for scientific and technological innovation and an important talent highland in the world; Sixthly, taking advantage of the situation to plan the construction of the “Science and Technology Innovation Special Zone” and advance the reform and opening-up in the new era.