The construction of the New Southwest Land-Sea Corridor directly connecting the southwest inland with the Indian Ocean has become a major project of the “Belt and Road” and the “opening up” of the southwest region to the sea. By constructing the new economic geography model of the three countries and four regions:the footloose capital model, this paper simulates five scenarios in the traditional eastern sea trade corridor, the opening of the new corridor, the high-level connectivity of the new corridor, the industrial subsidy policy supplemented by the transfer to the west, and the transport infrastructure investment policy promoting the connection between the west and the east. The results show that: (1) Under the traditional east sea trade corridor, deepening the opening policy of China is conducive to the industrial production shift to the large market in the east region, but this will further widen the gap between east and west; (2) After the opening of the New Southwest Land-Sea Corridor, the western inland of China will directly go to sea from the Indian Ocean. The trade cost will decrease, the trade and market scale will expand, and the local market effect will promote the industrial production to the west, which will narrow the gap between east and west.(3) Under the high-level connectivity of the new corridor, the competition for industrial capital distribution among the four regions is more intense. The channel effect between the western region and the Indian Ocean surrounding region is the most direct, and it can reverse its location disadvantage to a great extent. (4) Compared with the industrial subsidy policy assisted by the westward transfer, the transport infrastructure investment policy that promotes the connectivity of the western and eastern regions has an endogenous industrial transfer effect, which may help solve the “Hu Huanyong problem”.