This article presents three new propositions of digital industrial organization, namely industrial organization restructure and relational behavior, enterprise organizational restructure and its impact to individual behavior, as well as the relationship between macro-meso-micro economic organizations. It explores the trends of market structure change, industrial organization change of the digital economy, and regards three-level relational logics, such as digital industrial intra-organization, inter-organization and organization-individual, and their governance system. Consequently, the article tries to explain the fundamental theories of industrial organization change so as to highlight the policy-making in digital time.