Promoting the deep integration of technological innovation and industrial innovation represents a key mechanism for building a modern industrial system and fostering high-quality development. This study constructs an analytical framework from the perspective of multiple institutional logics to examine the integration of technological and industrial innovation. It systematically examines the tensions and coordination mechanisms among scientific, market, and administrative logics across four dimensions: assets, data, talent, and innovation outcomes. Using the Jiangsu Industrial Technology Research Institute as a case study, this research explores how a series of institutional innovations—including the grant-investment combination mechanism, technology manager system, trusted data spaces, and intellectual property empowerment reforms—facilitate a staged transformation from organizational framework establishment and operational model development to institutional consolidation. The findings reveal that multiple institutional logics exhibit a coexistence of conflict and coordination across different stages of innovation activities. The key to integrating technological and industrial innovation lies in establishing tailored institutional arrangements according to the characteristics of institutional logics at different stages, so as to achieve a dynamic balance among multiple logics. This study extends the application boundaries of institutional logic theory within the domain of technological and industrial innovation integration, and offers both theoretical and practical insights into the dynamic coordination mechanisms of multiple institutional logics within innovation systems.