This paper puts forward six great tre nds on the globalization of science a nd technology,i.e.,from the"space of place"to"space of flow",the growth rate of information and k nowledge exceeds that of materials,special attention paid to the global exploration of intellectual resour ces,from"zero game "to"non -zero game ",from mechanical mode to social mode a nd from reality to virtuality.It is s ignificant to have a sound understan ding on the above in the globalization of s cience and technology when making re levant policies.