Because of the development of the inf ormation technology,especially th e unceasing improvement of the computer capacity and the upsurge of the Internet,some traditional idea in the operation of the economy has been impacted to a certain degree on the on e hand and the social and economical c hanges will surely initiate the man-agement reform for the enterprises o n the other.The result caused by the management reform of the enterprises will lead to the reform of the economic increase modes and the improvement of th e competitive strength in the new e-conomic environment.Of course,the development and wide applications o f the information technology will br ing a long -term,enduring and deep -going influence to the enterprises.The re search on the management reform to th e enterprises initiated by the inform ation technology will also be an unin terrupted process.However,the com bination of the information technology and th e management science will be an inexorable trend in the management process of the enterprises in the future.This a rticle probes into the changes of the organizational structure,process and supply chain of the information technology under conditions of applications an d puts forward the most flexible system of the network organizations.In the resea rch of the process transformation,i t puts forward the customer' s guide and the analysis thinking of the value chain.In the analysis of the supply chain,it puts forward clearly that in the management of the supply chain,the m anagement of the information flow is the core so that it provides a certain line of thinking and methods for the m anagement of the enterprises under c onditions of the information technology.