Giant transnational corporations are key competitors among countries in the global market.The Fortune 500 that change economic structure and lead wor ld economy into development are representatives of transnational corporations.Th e paper analyses the structure and change about Fortune 500 and American and Jap an firms that are included the Fortune 500,and concludes that Chinese firms shou ld reform their industrial structure,develop High-Tech industry,set up new busi ness system that strengthens capital business and strategic alliance with an aim to strengthened in order to take part in international competition and adapt th emselves to economic globalization.