The geographical mediated knowledge spillover in regional innovation systems has been a major issue for new economic growth theory and new economic geography to study. Taking high - tech industry for example, the author makes the empirical study on the spatial scope and extent of knowledge spillovers in the universities with the knowledge production function framework and based on the spatial econometric theory. The result indicates that intra - region knowledge spillovers from university research to high technology innovations is positive and significant, however the extent of spillovers is low; High technology innovations have spatial dependence, and the knowledge production of the high technology sector in one location not only increases its own knowledge stocks, but also spillovers to the adjacent districts which will cause the increasing of knowledge stocks in the adjacent districts. The author puts forwards some policy suggestions to intensify knowledge production and spillovers according to the empirical results.