Industrial Symbiosis Network (ISN) is the main organization form for cooperating companies in Eco-Industrial Park (EIP). As the forming path of EIP varies, the operating pattern of ISN is different. Different operating pattern goes with different risk and efficiency, and in turn the safety and stability of ISN will be affected. With the reference to the trend of EIP across the world, this paper puts forward four types of representative operating patterns, which include relying on oriented, equaling oriented, nesting oriented and virtual oriented industrial symbiosis network. And then their operating mechanism, characteristics and risk are also analyzed. On this basis, in order to promote the construction of EIP in our country successfully, some countermeasures are proposed.