With the process of economic integration, the trade volumes of regional industry become more and more larger. Taking full advantages of themselves, different regions get win-win benefits by learning from other's strong points to offset their weakness in economic and trading activity that promote common development of regional economy. As the international trade, the rationality problem also exists in the structure of exchange products in regional industry. To inquire into its rationality is helpful to coordinate the development of regional economy scientifically and effectively, as well as to accelerate the formation of economic integration. Applying the regional input-output model, an empirical research on the rationality of exchange products structure in China's regional industry has been made.