Entrepreneurial creative decision-making (ECDM) is a kind of complex thinking and economic phenomenon. On the basis of research on complex thinking, the paper constructs the theoretical framework of entrepreneurial creative decision-making based on the new perspective of cognitive resource, which integrates cognitive science, decision science, creativity research. The paper explores the inherent mechanism of entrepreneurial creativity excited through fully excavating entrepreneurial unique cognitive resources. Furthermore, aspects of the design basis of cognitive motivational resources, the identification of intellectual disabilities and shielding strategies are discussed deeply as well.