The paper takes four representative enterprises of biology pharmacy in Chongqing as the research subjects,with multi-case analysis methods applied to explore the relationships among the enterprise enviorenments,the knowledge management strategy,and the enterprise performance.It is found that,for those enterprises that have implemented IT knowledge management strategy,capture knowledge management strategy or learned knowledge management strategy,when confronted with changes in dynamism,complexity and hostility of the environment,the effects of environment against enterprise performance vary.A brand-new conceptual model has been created herein.